THE POTENTIAL OF TRIMETHYLGLYCINE AS A MEANS OF THE COMPLEX REGULATION OF CARBOHYDRATE METABOLISM IN HYPERGLYCEMIA AND OBESITY

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DOI:

https://doi.org/10.30890/2709-2313.2024-34-00-006

Keywords:

trimethylglycine, hyperglycemia, non-alcoholic fatty liver disease, intestinal barrier, inflammation

Abstract

Type 2 diabetes is a common metabolic disease. At least one in ten people suffer from type 2 diabetes. At the same time, almost half of the cases of type 2 diabetes are associated with non-alcoholic fatty liver disease.It is known that the basis of the

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References

L Kalachniuk. P. Fedyshyn et other. (2021). Bio protectors’ effect on the composition of some amino acids under alcohol-induced oxidative stress. EUREKA: Life Sciences, (4), 50-57. DOI: https://doi.org/10.21303/2504-5695.2021.001985

Kalynovska, P. Fedyshyn, L. Kalachniuk et other. (2021). Vplyv betainu na endotelialni klityny. Visnyk Kyivskoho natsionalnoho universytetu imeni Tarasa Shevchenka. Biolohiia. [The effect of betaine on endothelial cells]. [Bulletin of the Taras Shevchenko National University of Kyiv. Biology.], 3(86), С.48-52. DOI: 10.17721/1728.2748.2021.86.48-53

David Højland Ipsen et other. (2018). Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. Cell Mol Life Sci, 75(18):3313-3327. DOI: 10.1007/s00018-018-2860-6

Agnieszka Karkucinska-Wieckowska et other. (2022). Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship. Eur J Clin Invest, 52(3):e13622. DOI:10.1111/eci.13622

Sebastian Friedrich Petry et other. (2022). Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro. Antioxidants (Basel), 15;11(4):788. DOI: 10.3390/antiox11040788

Ji Su Kim et other. (2022). Short-term control of diet affects cisplatin-induced acute kidney injury through modulation of mitochondrial dynamics and mitochondrial GSH. Physiol Rep, 10(12):e15348. DOI: 10.14814/phy2.15348

Mengmeng Zhang et other. (2016). Antioxidant Mechanism of trimethylglycine without Free Radical Scavenging Ability. J Agric Food Chem, 26;64(42):7921-7930. DOI: 10.1021/acs.jafc.6b03592

Hua Wang et other. (2021). Immunological mechanisms and therapeutic targets of fatty liver diseases. Cell Mol Immunol, 18(1): 73–91. DOI: 10.1038/s41423-020-00579-3

Yaru Li et other. (2022). Berberine Improves TNF-α-Induced Hepatic Insulin Resistance by Targeting MEKK1/MEK Pathway. Inflammation, 45(5):2016-2026. DOI: 10.1007/s10753-022-01671-8.

Xia Y et other. (2018). Trimethylglycine Inhibits Interleukin-1beta Production and Release: Potential Mechanisms. Front Immunol, 9:2670. DOI: 10.3389/fimmu.2018.02670

Anna Gudan et other. (2023). Small Intestinal Bacterial Overgrowth and Non-Alcoholic Fatty Liver Disease: What Do We Know in 2023?

Nutrients, 8;15(6):1323. DOI: 10.3390/nu15061323

NF-κB (NF-κB 信号通路). Available at: https://www.medchemexpress.cn/Pathways/NF-%CE%BAB.html

Published

2024-11-30

How to Cite

Kalachniuk, L., & Fedyshyn, P. (2024). THE POTENTIAL OF TRIMETHYLGLYCINE AS A MEANS OF THE COMPLEX REGULATION OF CARBOHYDRATE METABOLISM IN HYPERGLYCEMIA AND OBESITY. European Science, 2(sge34-02), 103–110. https://doi.org/10.30890/2709-2313.2024-34-00-006