GENETIC DATA OF MELATONIN’S ADIOPROTECTIVE EFFECT ON NON-MALIGNANT CELLS OF ONCOGYNECOLOGICAL PATIENTS

Authors

  • Emiliia Domina R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, https://orcid.org/0000-0002-1058-0489
  • Yryi Dumanskyi R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine
  • Ludmila Makovetska R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine

DOI:

https://doi.org/10.30890/2709-2313.2025-36-02-019

Keywords:

melatonin, radiotherapy, peripheral blood lymphocytes, cervical cancer, oncology

Abstract

Clinical radiobiologists and oncologists are interested in cervical cancer (CC) due to the risk of developing radiation complications in critical pelvic organs as a result of RT. There is an urgent need to develop nontoxic radioprotectors that would be se

Metrics

Metrics Loading ...

References

Domina E.A. Radiogenetic cancer epidemiology and primary prevention. “Scientific Book” project.Naukova dumka.-2016.-P.196.

Bristow R.G., Hill R.P., Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat. Rev. Cancer, 2008, 8:180-192.

Domina E.A. Radiation-induced instability of the human genome during low-dose irradiation. Сhapter in monograph «Heritage of European science 2024», 16 р. Karlsruhe, Germany.

Costa R.M., Chigancas V., Galhardo R.S. et al. The eukaryotic nucleotide excision repair pathway// Biochemie.-2003.-85,N11.-P.1083-1099.

Martin L.M., Marples B., Coffey M. et al. DNA mismatch repair and the damage response to ionizing radiation: making sense of apparently conflicting data// Cancer Treat. Revs.-2010-36, N 7.- P.518-527.

Domina E. A. Early and late radiation effects in healthy tissues of oncologic patients under therapeutic irradiations. Probl. Radiaс. Med. Radiobiol. 2017. Iss. 22. P. 23A27.

Domina E.A., Dumansky Y.V. Medical and radiobiological aspects of radiation complications in patients with oncogynaecological profile. Oncology. 2023. Т. 23, № 1. С. 9A15. DOI: https:/doi.org/10.15407/ oncology.2023.011.009.

Cancer in Ukraine, 2022A2023. Byuleten’ Natsional’noho kanA tserAreyestru Ukrayiny. 2024. No. 5. 129 p.

Ivankova V.S., Domina E.A., Matvievska L.V. et al. The use of iridium-192 in radiotherapy of vaginal cancer with radiobiological support. Ukr. Radiol. Zhurnal.2019.-27(2).- P.97-102.Ukrainian.

H. Jung, H. P. Beck-Bornholdt, V. Svoboda et al. Quantification of late complications after radiation therapy . Radiother. Oncol. 2001. Vol. 61. P. 233A246. doi: 10.1016/s0167A8140(01)00457A1.

Joyner MS, Kogel OG van der. Fundamentals of clinical radiobiology / transl. from Engl. M.: BІNOM. Laboratoriya znaniy, 2013. 600 р.

Domina E.A. Pathogenesis of radiation complications in normal tissues surrounding an irradiated tumour. Problems of Radiation Medicine and Radiobiology. 2024. -29:34A43. doi: 10.33145/2304A8336A2024A29A34A43.

P. P. Sorochan, I. S. Gromakova, N. E. Prokhach et al. MELATONIN ADMINISTRATION IN ONCOLOGY. INTERNATIONAL MEDICAL JOURNAL ‘ONCOLOGY’, 2012, № 3.

H. Fukunaga, A. Yokoya, Y. Taki et al. H. Fukunaga, A. Yokoya, Y. Taki et al. Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity? / Tohoku J Exp Med. 2019. Vol. 247. № 4, P. 223-235. doi: 10.1620/tjem.247.223.

A. Reddig, C.E. Rübe, S. Rödiger et al. DNA damage assessment and potential applications in laboratory diagnostics and precision medicine / J Lab Precis Med. 2018. Vol. 3, № 4. P. 1-15. doi: 10.21037/jlpm.2018.03.06.

Olive P.L., Banáth J.P. The comet assay: a method to measure DNA damage in individual cells. Nat prot. 2006. Vol. 1, № 1. Р. 23-29. doi:10.1038/nprot.2006.5.

Collins A.R. Investigating oxidative DNA damage and its repair using the comet assay. Mutat Res. 2009. Vol. 681, №. 1. P. 24-32. doi: 10.1016/j.mrrev.2007.10.002.

Ariga T, Toita T, Kasuya G, Nagai Y, Inamine M, Kudaka W, et al. External beam boost irradiation for clinically positive pelvic nodes in patients with uterine cervical cancer. J Radiat Res. 2013;54(4):690A 6. doi: 10.1093/jrr/rrs138.

Published

2025-01-30

How to Cite

Domina, E., Dumanskyi, Y., & Makovetska, L. (2025). GENETIC DATA OF MELATONIN’S ADIOPROTECTIVE EFFECT ON NON-MALIGNANT CELLS OF ONCOGYNECOLOGICAL PATIENTS. European Science, 2(sge36-02), 219–225. https://doi.org/10.30890/2709-2313.2025-36-02-019