THE LIFESTYLE HEART TRIAL: THE IMPACT OF INTENSIVE LIFESTYLE CHANGES ON CORONARY ARTERY DISEASE REVERSAL

Authors

DOI:

https://doi.org/10.30890/2709-2313.2025-37-02-017

Keywords:

Lifestyle Heart Trial, coronary artery disease, atherosclerosis, lifestyle modifications, plant-based diet, aerobic exercise, stress management, smoking cessation, cholesterol levels, low-density lipoprotein (LDL), high-density lipoprotein (HDL), coronary

Abstract

The Lifestyle Heart Trial was the first randomized clinical study to investigate whether comprehensive lifestyle modifications alone, without lipid-lowering drugs, could halt or reverse coronary atherosclerosis. The primary objective was to assess the fea

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References

Ornish DM, Scherwitz LW, Doody RS. et al. Effects of stress management training and dietary changes in treating ischemic heart disease. JAMA.1983;249:54-59.Google Scholar

Ornish DM, Gotto AM, Miller RR. et al. Effects of a vegetarian diet and selected yoga techniques in the treatment of coronary heart disease [abstract]. Clin Res.1979;27:720A.Google Scholar

Ornish DM, Brown SE, Scherwitz LW. et al. Can lifestyle changes reverse coronary atherosclerosis? The Lifestyle Heart Trial. Lancet.1990;336:129-133.Google Scholar

Gould KL, Ornish D, Kirkeeide R. et al. Improved stenosis geometry by quantitative coronary arteriography after vigorous risk factor modification. Am J Cardiol.1992;69:845-853.Google Scholar

Gould KL, Ornish D, Scherwitz L. et al. Changes in myocardial perfusion abnormalities by positron emission tomography after long-term, intense risk factor modification. JAMA.1995;274:894-901.Google Scholar

Stuff JE, Garza C, Smith EO. et al. A comparison of dietary methods in nutritional studies. Am J Clin Nutr.1983;37:300-306.Google Scholar

Ornish D. Reversing Heart Disease. New York, NY: Ballantine Books; 1992.

Billings J, Scherwitz L, Sullivan R, Ornish D. Group support therapy in the Lifestyle Heart Trial. In: Scheidt S, Allan R, eds. Heart and Mind: The Emergence of Cardiac Psychology. Washington, DC: American Psychological Association; 1996:233-253.

Moyers B. Changing life habits: a conversation with Dean Ornish. In: Healing and the Mind. New York, NY: Doubleday & Co Inc; 1993.

American College of Sports Medicine. Guidelines for Exercise Testing and Prescription. Philadelphia, Pa: Lea & Febiger; 1986.

SAS Institute Inc. SAS/STAT, Version 6.08: Changes and Enhancements, SAS Technical Report P-229. Cary, NC: SAS Institute; 1992.

Ornish D. More on low-fat diets. N Engl J Med.1998;338:1623-1624.Google Scholar

Brown BG, Alberts JJ, Fisher LD. et al. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med.1990;323:1289-1298.Google Scholar

Jukema JW, Bruschke AVG, Van Boven AJ. et al. Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. Circulation.1995;91:2528-2540.Google Scholar

Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease. Lancet.1994;344:1383-1389.Google Scholar

Haskell WL, Alderman EL, Fair JM. et al. Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. Circulation.1994;89:975-990.Google Scholar

Via JA, Treasure CB, Nabel EG. et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation.1990;81:491-497.Google Scholar

Harrison DG, Armstrong ML, Freimann PC. et al. Restoration of endothelium-dependent arterial relaxation by dietary treatment of atherosclerosis. Circulation.1987;80:1808-1811.Google Scholar

Shepherd J, Cobbe SM, Ford I. et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med.1995;333:1301-1307.Google Scholar

Hunninghake DB, Stein EA, Dujovne CA. et al. The efficacy of intensive dietary therapy alone or combined with lovastatin in outpatients with hypercholesterolemia. N Engl J Med.1993;328:1213-1219.Google Scholar

Stefanick ML, Mackey S, Sheehan M. et al. Effects of diet and exercise in men and postmenopausal women with low levels of HDL-C and high levels of LDL cholesterol. N Engl J Med.1998;339:12-20.Google Scholar

Katan MB, Grundy SM, Willett WC. Should a low-fat, high-carbohydrate diet be recommended for everyone? beyond low-fat diets. N Engl J Med.1997;337:563-567.Google Scholar

Lichtenstein AH, Van Horn L. Very low fat diets: AHA Science Advisory. Circulation.1998;98:935-939.Google Scholar

Brinton EA, Eisenberg S, Breslow JL. A low-fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates. J Clin Invest.1990;85:144-151.Google Scholar

Connor WE, Connor SL. Should a low-fat, high-carbohydrate diet be recommended for everyone? the case for a low-fat, high-carbohydrate diet. N Engl J Med.1997;337:562-563, 566.Google Scholar

King III SB, Lembo NJ, Weintraub WS. et al. A randomized trial comparing coronary angioplasty with coronary bypass surgery: Emory Angioplasty versus Surgery Trial (EAST). N Engl J Med.1994;331:1044-1050.Google Scholar

Ornish D. Dietary treatment of hyperlipidemia. J Cardiovasc Risk.1994;1:283-286.Google Scholar

Morrison LM. Diet in coronary atherosclerosis. JAMA.1960;173:884-888.Google Scholar

Esselstyn Jr CB, Ellis SG, Medendorp SV, Crowe TD. A strategy to arrest and reverse coronary artery disease: a 5-year longitudinal study of a single physician's practice. J Fam Pract.1995;41:560-568.Google Scholar

Ornish D. Avoiding revascularization with lifestyle changes: The Multicenter Lifestyle Demonstration Project. Am J Cardiol.1998;82:72T-76T.Google Scholar

Avorn J, Monette J, Lacour A. et al. Persistence of use of lipid-lowering medications. JAMA.1998;279:1458-1462.Google Scholar

Newman TB, Hulley SB. Carcinogenicity of lipid-lowering drugs. JAMA.1996;275:55-60.Google Scholar

Published

2025-02-28

How to Cite

Alsalama, M., Rusnak, I., & Balan, A. (2025). THE LIFESTYLE HEART TRIAL: THE IMPACT OF INTENSIVE LIFESTYLE CHANGES ON CORONARY ARTERY DISEASE REVERSAL. European Science, 2(sge37-02), 16–21. https://doi.org/10.30890/2709-2313.2025-37-02-017