L-ARGININE SUPPLEMENTATION IN ANTIHYPERTENSIVE THERAPY: A NOVEL APPROACH TO ENDOTHELIAL AND METABOLIC CORRECTION IN INSULIN-RESISTANT PATIENTS
DOI:
https://doi.org/10.30890/2709-2313.2025-39-02-06Keywords:
arterial hypertension, insulin resistance, L- arginine, endothelial dysfunction, lipid metabolismAbstract
This study explored vascular motor responses, as well as lipid and carbohydrate metabolism in patients with arterial hypertension and insulin resistance, identifying key features of endothelial dysfunction and novel therapeutic strategies. The clinical efMetrics
References
Horbas’ IM. The Control over arterial hypertension of the population: the state of the problem according to the data of epidemiolagic researches. Ukrainian Cardiologic Magazine. 2007;2:21–26.
Horbas’ IM. Epidemiology of the main risk factors of cardio-vascular diseases. Arterial hypertension. 2008;2(2):12–18.
GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2016;390:1345–422.
Polivoda SN. Endothelial dysfunction at hypertonic disease: pathophsiological formation mechanisms. Arterial Hypertension. 2009;5(7):29–34.
Orlova NN, Yevstratova IN, Vasilenchuk NN., Mhitaryan LS. The activity of free radical oxidative reactions and the condition of lipid metabolism at hypertonic disease. Ukr. Cardiol. Magazine. 2009;5:56–61.
Scaglione R, di Chiara T, Cariello T, Licata G. Visceral obesity and metabolic syndrome: two faces of the same medal? Intern. Emerg. Med. 2009;9:387–392.
Amosova YeN, Myasnikov GV, SIdorova LL. The carbohydrate and lipid meabolism condition of the patients with arterial hypertension with a preserved tissue sensitivity to insulin and the syndrome of insulin resistance. Ukrainian Therapeutical magazine. 2007;2:17–25.
Orynchak МA, Chovganiuk OS, Artemenko NR. Insulin resistance as a risk factor for the development of cardio-vascular diseases of elderly people. Bukovinian medical herald. 2009;13(4):212–213.
Mustafa S, Sharma V, McNeill JN. Insulin resistance and endothelial dysfunction: Are epoxyeicosatrienoic acids the link? Br. Journ. Pharmacol. 2009;157(4):527–536.
Marchesi C, Ebrahimian T, Angulo O. Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension. 2009;54(6):1384–1392.
Tziomalos K, Athyros VG, Karagiannis A, Mikhailidis DP. Endothelial dysfunction in metabolic syndrome: Prevalence, pathogenesis and management. Nutr. Metab. Cardiovasc. Dis. 200913. – P. 25;6–258.
Kompendium 2008 - Medications (2008) V.N. Kovalenko, A.P. Viktorov (editor.) MORION, Kyiv, р. 2270.
McAuley KA, Sheila M, Mann JI. Diagnosing Insulin Resistance in the General Population Diabetes. Care. 2001;24:460–464.
Gkaliagkousi E, Douma S, Zamboulis C, Ferro A. Nitric oxide dysfunction in vascular endothelium and platelets: role in essential hypertension Journ. Hypertens. 2009;27(12):2310–2320.
De la Sierra A, Larrousse M. Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension. Journ. Hum. Hypertens. 2009;26:324–329.
Tziomalos K, Athyros VG, Karagiannis A, Mikhailidis DP. Endothelial dysfunction in metabolic syndrome: Prevalence, pathogenesis and management. Nutr. Metab. Cardiovasc. Dis. 2009;13:256–258.
Marchesi C, Ebrahimian T, Angulo O. Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension. 2009;54(6):1384–1392.
Lekakis JP, Papathanassiou S, Papaioan-nou TG. Oral L-arginine improves endothelial dysfunction in patients with essential hypertension. Int. J. Cardiol. 2002;86(2–3):317–323.
Palloshi A, Fragasso G, Piatti P. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries. Am. J. Cardiol. 2004;93(7):933-935.
Lucotti P, Monti L, Setola E. Oral L-arginine supplementation improves endothe-lial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass. Metabolism. 2009;58(9):1270-1276.
Piatti PM, Monti LD, Valsecchi G. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 2001;24(5):875–880.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
