BIOMARKERS OF MYOCARDIAL REMODELING AND CORONARY RESERVE IN PATIENTS WITH STABLE ANGINA: THE PROGNOSTIC ROLE OF URIC ACID, NT-PROBNP AND CRP

Authors

DOI:

https://doi.org/10.30890/2709-2313.2025-40-02-008

Keywords:

stable angina, Uric acid, NT-proBNP, C-reactive protein (CRP), Myocardial remodeling, Coronary reserve, Left ventricular ejection fraction (LVEF), Cardiovascular biomarkers, Cardiac function, Exercise tolerance, Ischemia, Heart failure, Predictive markers

Abstract

Introduction. In recent years, there has been an increasing focus on cardiovascular biomarkers due to the demand for non-invasive diagnostic tools capable of predicting the progression of atherosclerotic cardiovascular disease (ASCVD). Among the various

Metrics

Metrics Loading ...

References

Jeong S-M, Kang M-J, Choi H-N et al (2012) Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice. Nutr Res Pract 6(3): 201.

Jin M, Yang F, Yang I et al (2012) Uric acid, hyperuricemia and vascular diseases. Front Biosci (Landmark Ed) 17: 656-669.

Jones TH Testosterone deficiency: a risk factor for cardiovascular disease? Trends Enlocrinol Metab 21: 496–503.

Kanbay M, Segal M, Afsar B et al (2013) The role of uric acid in the pathogenesis of human cardiovascular disease. Heart 99(11): 759-766.

Kanbay M, Siriopol D, Nistor I et al (2014) Effects of allopurinol on endothelial dysfunction: a meta-analysis. Am J Nephrol 39(4): 348-356.

Kawada T, Andou T, Fukumitsu M (2016) Metabolic syndrome showed significant relationship with carotid atherosclerosis. Heart Vessels 31(5): 664-670.

Kim SC, Schneeweiss S, Choudhry N et al (2015) Effects of xanthine oxidase inhibitors on cardiovascular disease in patients with gout: a cohort study. Am J Med 128(6): 653.

Klafke JZ, Porto FG, Batista R et al (2015) Association between hypertriglyceridemia and protein oxidation and proinflammatory markers in normocholesterolemic and hypercholesterolemic individuals. Clin Chim Acta 448: 50-57.

Kleber ME, Delgado G, Grammer TB et al (2015) Uric Acid and Cardiovascular Events: A Mendelian Randomization Study. J Am Soc Nephrol 26(11): 2831-2838.

Kloner RA, Carson C, Dobs A et al (2016) Testosterone and Cardiovascular Disease. J Am Coll Cardiol 67(5): 545-557.

Kube J, Ebner N, Jankowska EA et al (2016) The influence of confounders in the analysis of mid-regional pro-atrial natriuretic peptide in patients with chronic heart failure. Int J Cardiol 219: 84-91.

Kumar S, Pandey AK (2013) Chemistry and Biological Activities of Flavonoids: An Overview. Sci World J 2013: 1–16.

Kuo D, Crowson CS, Gabriel SE et al (2014) Hyperuricemia and Incident Cardiovascular Disease and Noncardiac Vascular Events in Patients with Rheumatoid Arthritis. Int J Rheumatol 2(1): 22-25.

Kuwabara M (2016) Hyperuricemia, Cardiovascular Disease, and Hypertension. Pulse (Basel) 3(3-4): 242-252.

Lai J, Ge Y, Shao Y et al (2015) Low serum testosterone level was associated with extensive coronary artery calcification in elderly male patients with stable coronary artery disease. Coron Artery Dis 26(5): 437-441.

Laughlin GA, Goodell V, Barrett-Connor E et al (2010) Extremes of endogenous testosterone are associated with increased risk of incident coronary events in older women. J Clin Endocrinol Metab 95(2): 740-747.

Lazzeri C, Valente C, Chiostri M (2015) Uric acid and mild renal impairment in patients with ST-elevation myocardial infarction. Scand Cardiovasc 49(1): 14-19.

Leistner DM, Klotsche J, Pieper L (2013) Prognostic value of NT-pro-BNP and hs-CRP for risk stratification in primary care: results from the population-based DETECT study. Clin Res Cardiol 102(4): 259-268.

Li P, Luo Y, Chen YM (2013) B-type natriuretic peptide-guided chronic heart failure therapy: a meta-analysis of 11 randomised controlled trials. Heart Lung Circ 22(10): 852-860.

Lin JC, Lin CL, Chen MC et al (2015) Gout, not hyperuricemia alone, impairs left ventricular diastolic function. Arthritis Res Ther 17(1): 323.

Liu YH, Liu Y, Zhou YK et al (2015) Association of N-terminal pro-B-type natriuretic peptide with contrast-induced nephropathy and long-term outcomes in patients with chronic kidney disease and relative preserved left ventricular function. Medicine (Baltimore) 94(13): e358.

Liu P, Wang H, Zhang F et al (2015) The Effects of Allopurinol on the Carotid Intima-media Thickness in Patients with Type 2 Diabetes and Asymptomatic Hyperuricemia: A Three-year Randomized Parallel-controlled Study. Intern Med 54(17): 2129-2137.

Mahmoodi MR, Baneshi MR, RastegariA (2015) Comparison of conventional risk factors in middle-aged versus elderly diabetic and nondiabetic patients with myocardial infarction: prediction with decision-analytic model. Ther Adv Endocrinol Metab 6(6): 258-266.

MacDonald TM, Ford I, Nuki G et al (2014) Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST): a large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia. BMJ Open 4(7): e005354.

Malik R, Aneni EC, Shahrayar S et al (2016) Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging. Aging Clin Exp Res 28(2): 359-362.

Mancia G, Grassi G, Borghi C (2015) Hyperuricemia, urate deposition and the association with hypertension. Curr Med Res Opin 2: 15-19.

Mehta V, Sukhija R, Mehra P et al (2016) Multimarker risk stratification approach and cardiovascular outcomes in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention. Indian Heart J 68(1): 57-62.

Meimoun P, Germain AL, Elmkies F et al (2012) Factors associated with noninvasive coronary flow reserve in severe aortic stenosis. J Am Soc Echocardiogr 25(8): 835-841.

Mirhafez SR, Ebrahimi M, Saberi Karimian M et al (2016) Serum high-sensitivity C-reactive protein as a biomarker in patients with metabolic syndrome: evidence-based study with 7284 subjects. Eur J Clin Nutr 70(11): 1298-1304.

Mishra RK, Beatty AL, Jaganath R et al (2014) B-type natriuretic peptides for the prediction of cardiovascular events in patients with stable coronary heart disease: the Heart and Soul Study. J Am Heart Assoc 3(4): e000907.

Mitchell A, Misialek JR, Folsom AR et al (2015) Usefulness of N-terminal Pro-brain Natriuretic Peptide and Myocardial Perfusion in Asymptomatic Adults (from the Multi-Ethnic Study of Atherosclerosis). Am J Cardiol 115(10): 1341-1345.

Montalescot G, Sechtem U, Achenbachs et al (2013) 2013 ESC guidelines on the management of stable coronary artery disease: The Task Force on the management ofstable coronary artery disease of the European Society of Cardiology. Eur Heart J 34(38): 2949–3003.

Published

2025-05-30

How to Cite

Balan, A., Tashchuk, V., Malinevska-Biliychuk, O., & Alsalama, M. (2025). BIOMARKERS OF MYOCARDIAL REMODELING AND CORONARY RESERVE IN PATIENTS WITH STABLE ANGINA: THE PROGNOSTIC ROLE OF URIC ACID, NT-PROBNP AND CRP. European Science, 2(sge40-02), 183–191. https://doi.org/10.30890/2709-2313.2025-40-02-008